Allelic silencing at the tumor-suppressor locus 13q14.3 suggests an epigenetic tumor-suppressor mechanism

Genomic material from chromosome band 13q14.3 distal to the retinoblastoma locus is recurrently lost in a variety of human neoplasms, indicating an as-yet-unidentified tumor-suppressor mechanism. No pathogenic mutations have been found in the minimally deleted region until now. However, in B cell ch...

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Autori principali: Mertens, Daniel, Wolf, Stephan, Tschuch, Cordula, Mund, Cora, Kienle, Dirk, Ohl, Sibylle, Schroeter, Petra, Lyko, Frank, Döhner, Hartmut, Stilgenbauer, Stephan, Lichter, Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2006
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472515/
https://ncbi.nlm.nih.gov/pubmed/16684883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600494103
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