Virucidal Activity of a GT-Rich Oligonucleotide against Herpes Simplex Virus Mediated by Glycoprotein B

We have investigated the antiviral mechanism of a phosphorothioate oligonucleotide, ISIS 5652, which has activity against herpes simplex virus (HSV) in the low micromolar range in plaque reduction assays. We isolated a mutant that is resistant to this compound. Marker rescue and sequencing experimen...

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Detalhes bibliográficos
Main Authors: Shogan, Benjamin, Kruse, Lori, Mulamba, Gilbert B., Hu, André, Coen, Donald M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472053/
https://ncbi.nlm.nih.gov/pubmed/16641267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.10.4740-4747.2006
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