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The effect of structure in a long target RNA on ribozyme cleavage efficiency.

Inhibition of gene expression by catalytic RNA (ribozymes) requires that ribozymes efficiently cleave specific sites within large target RNAs. However, the cleavage of long target RNAs by ribozymes is much less efficient than cleavage of short oligonucleotide substrates because of higher order struc...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Campbell, T B, McDonald, C K, Hagen, M
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1997
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC147166/
https://ncbi.nlm.nih.gov/pubmed/9396806
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