Kinetics of phosphorothioate oligonucleotide metabolism in biological fluids.

The in vitro stability and metabolism of GEM[91, a 25mer phosphorothioate antisense oligonucleotide complementary to the gag mRNA region of HIV-1, was investigated using capillary electrophoresis (CE). The in vitro degradation of the parent compound at 37 degrees C was followed over the course of 12...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Gilar, M, Belenky, A, Smisek, D L, Bourque, A, Cohen, A S
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 1997
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146928/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9278481/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.18.3615
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