Modification of DNA duplexes to smooth their thermal stability independently of their base content for DNA sequencing by hybridization.

The possibility of equalizing DNA duplex stability is essential for the application of sequencing by hybridization. In this paper we describe a new strategy to obtain DNA duplexes with a thermal stability independent of their base content. Modified *C bases have been developed and incorporated into...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Nguyen, H K, Auffray, P, Asseline, U, Dupret, D, Thuong, N T
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 1997
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146866/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9224605/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.15.3059
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