Cysteine 50 of the POU H domain determines the range of targets recognized by POU proteins.

The best target of POU proteins (Oct-1, Oct-2) is an octamer sequence ATGCAAAT. POU proteins also recognize, with weaker affinity, the TAAT-like targets of another group of regulatory factors, the homeoproteins. Up to now, it has not been known why Cys50 of the POUHdomain is absolutely conserved in...

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Bibliografiske detaljer

Udgivet i:	Nucleic Acids Res
Principais autores:	Stepchenko, A G, Luchina, N N, Pankratova, E V
Format:	Artigo
Sprog:	Inglês
Udgivet:	Oxford University Press 1997
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146835/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9207034/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.14.2847
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