Cre recombinase-mediated restoration of nigrostriatal dopamine in dopamine-deficient mice reverses hypophagia and bradykinesia

A line of dopamine-deficient (DD) mice was generated to allow selective restoration of normal dopamine signaling to specific brain regions. These DD floxed stop (DDfs) mice have a nonfunctional Tyrosine hydroxylase (Th) gene because of insertion of a Neo(R) gene flanked by lox P sites targeted to th...

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Bibliografiske detaljer
Main Authors: Hnasko, Thomas S., Perez, Francisco A., Scouras, Alex D., Stoll, Elizabeth A., Gale, Samuel D., Luquet, Serge, Phillips, Paul E. M., Kremer, Eric J., Palmiter, Richard D.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2006
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1466546/
https://ncbi.nlm.nih.gov/pubmed/16723393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603081103
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