Steric factors influencing hybridisation of nucleic acids to oligonucleotide arrays.

We have investigated the use of spacer molecules to reduce steric interference of the support on the hybridisation behaviour of immobilised oligonucleotides. These spacers are built up from a variety of monomeric units, using phosphoramidite chemistry, by condensation onto an amine-functionalised po...

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Bibliographic Details

Published in:	Nucleic Acids Res
Main Authors:	Shchepinov, M S, Case-Green, S C, Southern, E M
Format:	Artigo
Language:	Inglês
Published:	Oxford University Press 1997
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146580/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9092624/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.6.1155
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