Significance of the conserved amino acid sequence for human MTH1 protein with antimutator activity.

8-Oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate (8-oxo-dGTP) is produced during normal cellular metabolism, and incorporation into DNA causes transversion mutation. Organisms possess an enzyme, 8-oxo-dGTPase, which catalyzes the hydrolysis of 8-oxo-dGTP to the corresponding nucleoside monophosph...

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Publié dans:	Nucleic Acids Res
Auteurs principaux:	Cai, J P, Kawate, H, Ihara, K, Yakushiji, H, Nakabeppu, Y, Tsuzuki, T, Sekiguchi, M
Format:	Artigo
Langue:	Inglês
Publié:	Oxford University Press 1997
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146569/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9092626/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.6.1170
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