Redox state regulates binding of p53 to sequence-specific DNA, but not to non-specific or mismatched DNA.
Redox modulation of wild-type p53 plays a role in sequence-specific DNA binding in vitro . Reduction produces a DNA-binding form of the protein while oxidation produces a non-DNA-binding form. Primer extension analysis reveals that increasing concentrations of reduced p53 result in enhanced protecti...
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| Publicado no: | Nucleic Acids Res |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146562/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9092641/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.6.1289 |
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