Redox state regulates binding of p53 to sequence-specific DNA, but not to non-specific or mismatched DNA.

Redox modulation of wild-type p53 plays a role in sequence-specific DNA binding in vitro . Reduction produces a DNA-binding form of the protein while oxidation produces a non-DNA-binding form. Primer extension analysis reveals that increasing concentrations of reduced p53 result in enhanced protecti...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Parks, D, Bolinger, R, Mann, K
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 1997
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146562/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9092641/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.6.1289
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