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Effect of geometric isomerism in dinuclear platinum antitumour complexes on the rate of formation and structure of intrastrand adducts with oligonucleotides.

The dinuclear platinum complexes [[trans -PtCl (NH3)2]2[mu]-[NH2(CH2) n NH2]](NO3)2[1,1/t,t ( n = 4,6)] and [[cis-PtCl(NH3)2]2[mu];-[NH2(CH2) n NH2](NO3) 2[1,1/c,c ( n = 4,6)] exhibit antitumour activity comparable with cisplatin. 1,1/c,c complexes do not form 1,2 GG intrastrand adducts, the major a...

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Udgivet i:Nucleic Acids Res
Principais autores: Mellish, K J, Qu, Y, Scarsdale, N, Farrell, N
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146552/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9092638/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.6.1265
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