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A pharmacologic target of G3139 in melanoma cells may be the mitochondrial VDAC
G3139, an 18-mer phosphorothioate antisense oligonucleotide targeted to the initiation codon region of the Bcl-2 mRNA, can induce caspase-dependent apoptosis via the intrinsic mitochondrial pathway in 518A2 and other melanoma cells. G3139-mediated apoptosis appears to be independent of its ability t...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1464367/ https://ncbi.nlm.nih.gov/pubmed/16648253 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602217103 |
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