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Phosphorothioate Oligonucleotides Block the VDAC Channel

Proapoptotic phosphorothioate oligonucleotides such as G3139 (an 18-mer) induce Bcl-2-independent apoptosis, perhaps partly via direct interaction with VDAC and reduction of metabolite flow across the mitochondrial outer membrane. Here, we analyzed the interactions at the molecular level. Ten microm...

詳細記述

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書誌詳細
主要な著者: Tan, Wenzhi, Loke, Yue-Hin, Stein, C. A., Miller, Paul, Colombini, Marco
フォーマット: Artigo
言語:Inglês
出版事項: The Biophysical Society 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1929033/
https://ncbi.nlm.nih.gov/pubmed/17483171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.105379
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