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Phosphorothioate Oligonucleotides Block the VDAC Channel
Proapoptotic phosphorothioate oligonucleotides such as G3139 (an 18-mer) induce Bcl-2-independent apoptosis, perhaps partly via direct interaction with VDAC and reduction of metabolite flow across the mitochondrial outer membrane. Here, we analyzed the interactions at the molecular level. Ten microm...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Biophysical Society
2007
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1929033/ https://ncbi.nlm.nih.gov/pubmed/17483171 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.105379 |
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