Regulation of lactate production at the onset of ischaemia is independent of mitochondrial NADH/NAD(+): insights from in silico studies

Ischaemia decreases mitochondrial NADH oxidation, activates glycolysis, increases the NADH/NAD(+) ratio, and causes lactate production. The mechanisms that regulate anaerobic glycolysis and the NADH/NAD(+) ratio during ischaemia are unclear. Although continuous measurements of metabolic fluxes and N...

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Detalhes bibliográficos
Main Authors: Zhou, Lufang, Stanley, William C, Saidel, Gerald M, Yu, Xin, Cabrera, Marco E
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2005
Assuntos:
Integrative Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1464269/
https://ncbi.nlm.nih.gov/pubmed/16223766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2005.093146
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