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Distamycin prolongs E-selectin expression by interacting with a specific NF-kappaB-HMG-I(Y) binding site in the promoter.

The E-selectin cell adhesion protein plays a critical role in mediating adherence of leukocytes to endothelium at sites of inflammation. Cytokine-induced E-selectin expression on the surface of endothelial cells is transient; mRNA expression peaks at 3-4 h after induction and returns to basal levels...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Ghersa, P, Whelan, J, Cambet, Y, DeLamarter, J F, Hooft van Huijsduijnen, R
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1997
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC146425/
https://ncbi.nlm.nih.gov/pubmed/9016563
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