Distamycin prolongs E-selectin expression by interacting with a specific NF-kappaB-HMG-I(Y) binding site in the promoter.

Eitemau Tebyg

• Two distinct NF-kappa B complexes differing in their larger subunit bind the E-selectin promoter kappa B element.
  gan: Hooft van Huijsduijnen, R, et al.
  Cyhoeddwyd: (1993)
• Cyclic AMP-independent ATF family members interact with NF-kappa B and function in the activation of the E-selectin promoter in response to cytokines.
  gan: Kaszubska, W, et al.
  Cyhoeddwyd: (1993)
• An NF kappa B-like factor is essential but not sufficient for cytokine induction of endothelial leukocyte adhesion molecule 1 (ELAM-1) gene transcription.
  gan: Whelan, J, et al.
  Cyhoeddwyd: (1991)
• Cooperativity between two NF-kappa B complexes, mediated by high-mobility-group protein I(Y), is essential for cytokine-induced expression of the E-selectin promoter.
  gan: Lewis, H, et al.
  Cyhoeddwyd: (1994)
• I kappaB alpha-independent downregulation of NF-kappaB activity by glucocorticoid receptor.
  gan: Heck, S, et al.
  Cyhoeddwyd: (1997)