IP(3)-mediated Ca(2+) increases do not involve the ryanodine receptor, but ryanodine receptor antagonists reduce IP(3)-mediated Ca(2+) increases in guinea-pig colonic smooth muscle cells

Smooth muscle responds to IP(3)-generating (sarcolemma acting) neurotransmitters and hormones by releasing Ca(2+) from the sarcoplasmic reticulum (SR) via IP(3) receptors (IP(3)Rs). This release may propagate as Ca(2+) waves. The Ca(2+) signal emanating from IP(3) generation may be amplified by its...

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Detalhes bibliográficos
Main Authors: MacMillan, Debbi, Chalmers, Susan, Muir, Thomas C, McCarron, John G
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2005
Assuntos:
Cell Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1464235/
https://ncbi.nlm.nih.gov/pubmed/16195318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2005.096529
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