Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

The innate immune system recognizes viral dsRNA through two distinct pathways; the Toll-like receptor 3 (TLR3) pathway detects dsRNA phagocytosed in endosomes; the helicases retinoic acid-induced protein I (RIG-I) and melanoma differentiation-associated gene-5 (mda-5) detect cytoplasmic dsRNA genera...

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Hlavní autoři: Gitlin, Leonid, Barchet, Winfried, Gilfillan, Susan, Cella, Marina, Beutler, Bruce, Flavell, Richard A., Diamond, Michael S., Colonna, Marco
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2006
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1464000/
https://ncbi.nlm.nih.gov/pubmed/16714379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603082103
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