Inhibition of melanoma tumor growth in vivo by survivin targeting

A role of apoptosis (programmed cell death) in tumor formation and growth was investigated by targeting the apoptosis inhibitor survivin in vivo. Expression of a phosphorylation-defective survivin mutant (Thr(34)→Ala) triggered apoptosis in several human melanoma cell lines and enhanced cell death i...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Grossman, Douglas, Kim, Paul J., Schechner, Jeffrey S., Altieri, Dario C.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2001
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC14640/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11149963/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.230450097
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