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Genetic polymorphism of mephenytoin p(4')-hydroxylation: difference between Orientals and Caucasians.

The genetically controlled mephenytoin p(4')-hydroxylation capacity was determined in 118 Caucasians and 70 Orientals. After an oral dose of 50 or 100 mg of racemic mephenytoin, the amount of p(4')-hydroxymephenytoin in 24 h urine was measured by gas chromatography. Bimodal distribution wa...

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Bibliografske podrobnosti
Main Authors: Jurima, M, Inaba, T, Kadar, D, Kalow, W
Format: Artigo
Jezik:Inglês
Izdano: 1985
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1463809/
https://ncbi.nlm.nih.gov/pubmed/3994895
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