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Pharmacokinetics of primaquine in man: identification of the carboxylic acid derivative as a major plasma metabolite.

A method is described for the simultaneous determination of the carboxylic acid and N-acetyl-derivatives of primaquine, in plasma and urine. After oral administration of 45 mg primaquine, to five healthy volunteers, absorption was rapid, with peak primaquine levels of 153.3 +/- 23.5 ng/ml at 3 +/- 1...

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Detalhes bibliográficos
Main Authors: Mihaly, G W, Ward, S A, Edwards, G, Orme, M L, Breckenridge, A M
Formato: Artigo
Idioma:Inglês
Publicado em: 1984
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1463409/
https://ncbi.nlm.nih.gov/pubmed/6721990
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