Polymorphic metabolism of β-adrenoceptor antagonists

1 Most β-adrenoceptor blockers undergo extensive oxidative metabolism. The evidence for polymorphism of the debrisoquine type is reviewed. 2 The AUC and half-life of metoprolol were considerably greater in poor metabolisers (PM) of debrisoquine than in extensive metabolisers (EM). Metoprolol α-hydro...

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Autors principals: Silas, J. H., Lennard, M. S., Tucker, G. T., Ramsay, L. E., Woods, H. F.
Format: Artigo
Idioma:Inglês
Publicat: 1984
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Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1463263/
https://ncbi.nlm.nih.gov/pubmed/6146335
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