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pH-dependent conformational switch activates the inhibitor of transcription elongation
Gfh1, a transcription factor from Thermus thermophilus, inhibits all catalytic activities of RNA polymerase (RNAP). We characterized the Gfh1 structure, function and possible mechanism of action and regulation. Gfh1 inhibits RNAP by competing with NTPs for coordinating the active site Mg(2+) ion. Th...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2006
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1462974/ https://ncbi.nlm.nih.gov/pubmed/16628221 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601094 |
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