Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors

The fungal pathogen Candida albicans has a multilayered cell wall composed of an outer layer of proteins glycosylated with N- or O-linked mannosyl residues and an inner skeletal layer of β-glucans and chitin. We demonstrate that cytokine production by human mononuclear cells or murine macrophages wa...

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Auteurs principaux: Netea, Mihai G., Gow, Neil A.R., Munro, Carol A., Bates, Steven, Collins, Claire, Ferwerda, Gerben, Hobson, Richard P., Bertram, Gwyneth, Hughes, H. Bleddyn, Jansen, Trees, Jacobs, Liesbeth, Buurman, Ed T., Gijzen, Karlijn, Williams, David L., Torensma, Ruurd, McKinnon, Alistair, MacCallum, Donna M., Odds, Frank C., Van der Meer, Jos W.M., Brown, Alistair J.P., Kullberg, Bart Jan
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2006
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1462942/
https://ncbi.nlm.nih.gov/pubmed/16710478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI27114
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