Identification of a functional domain within the essential core of histone H3 that is required for telomeric and HM silencing in Saccharomyces cerevisiae.

Fourteen novel single-amino-acid substitution mutations in histone H3 that disrupt telomeric silencing in Saccharomyces cerevisiae were identified, 10 of which are clustered within the alpha1 helix and L1 loop of the essential histone fold. Several of these mutations cause derepression of silent mat...

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Main Authors: Thompson, Jeffrey S, Snow, Marilyn L, Giles, Summer, McPherson, Leslie E, Grunstein, Michael
格式: Artigo
語言:Inglês
出版: 2003
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1462409/
https://ncbi.nlm.nih.gov/pubmed/12586729
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