Dissecting the fidelity of bacteriophage RB69 DNA polymerase: site-specific modulation of fidelity by polymerase accessory proteins.

Bacteriophage RB69 encodes a replicative B-family DNA polymerase (RB69 gp43) with an associated proofreading 3' exonuclease. Crystal structures have been determined for this enzyme with and without DNA substrates. We previously described the mutation rates and kinds of mutations produced in viv...

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Autores principales: Bebenek, Anna, Carver, Geraldine T, Dressman, Holly Kloos, Kadyrov, Farid A, Haseman, Joseph K, Petrov, Vasiliy, Konigsberg, William H, Karam, Jim D, Drake, John W
Formato: Artigo
Lenguaje:Inglês
Publicado: 2002
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1462346/
https://ncbi.nlm.nih.gov/pubmed/12454051
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