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Biased estimation of the recombination fraction using half-sib families and informative offspring.

A maximum-likelihood method to estimate the recombination fraction and its sampling variance using informative and noninformative half-sib offspring is derived. Estimates of the recombination fraction are biased up to 20 cM when noninformative offspring are discarded. In certain scenarios, the sampl...

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Bibliografske podrobnosti
Glavni avtor: Gomez-Raya, L
Format: Artigo
Jezik:Inglês
Izdano: 2001
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1461567/
https://ncbi.nlm.nih.gov/pubmed/11238420
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