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The Dunce cAMP Phosphodiesterase PDE-4 Negatively Regulates Gα(s)-Dependent and Gα(s)-Independent cAMP Pools in the Caenorhabditis elegans Synaptic Signaling Network
Forward genetic screens for mutations that rescue the paralysis of ric-8 (Synembryn) reduction-of-function mutations frequently reveal mutations that cause hyperactivation of one or more components of the Gα(s) pathway. Here, we report that one of these mutations strongly reduces the function of the...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Copyright © 2006 by the Genetics Society of America
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1461419/ https://ncbi.nlm.nih.gov/pubmed/16624912 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.105.054007 |
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