A role for cytosolic hsp70 in yeast [PSI(+)] prion propagation and [PSI(+)] as a cellular stress.

[PSI(+)] is a prion (infectious protein) of Sup35p, a subunit of the Saccharomyces cerevisiae translation termination factor. We isolated a dominant allele, SSA1-21, of a gene encoding an Hsp70 chaperone that impairs [PSI(+)] mitotic stability and weakens allosuppression caused by [PSI(+)]. While [P...

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Hlavní autoři: Jung, G, Jones, G, Wegrzyn, R D, Masison, D C
Médium: Artigo
Jazyk:Inglês
Vydáno: 2000
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1461277/
https://ncbi.nlm.nih.gov/pubmed/11014806
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