Towards artificial ribonucleases: the sequence-specific cleavage of RNA in a duplex.
Lanthanide complexes covalently attached to oligonucleotides have been shown to cleave RNA in a sequence-specific manner. Efficient cleavage, however, is at present limited to single-stranded RNA regions, as RNA in a duplex is considerably more resistant to strand scission. To overcome this limitati...
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| Published in: | Nucleic Acids Res |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Oxford University Press
1996
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146125/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8836177/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.18.3522 |
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