Transcriptional repression by Rev-erbA alpha is dependent on the signature motif and helix 5 in the ligand binding domain: silencing does not involve an interaction with N-CoR.

Ítems similars

• Transcriptional repression by the orphan steroid receptor RVR/Rev-erb beta is dependent on the signature motif and helix 5 in the E region: functional evidence for a biological role of RVR in myogenesis.
  per: Burke, L, et al.
  Publicat: (1996)
• Two receptor interaction domains in the corepressor, N-CoR/RIP13, are required for an efficient interaction with Rev-erbA alpha and RVR: physical association is dependent on the E region of the orphan receptors.
  per: Downes, M, et al.
  Publicat: (1996)
• A functional Rev-erb alpha responsive element located in the human Rev-erb alpha promoter mediates a repressing activity.
  per: Adelmant, G, et al.
  Publicat: (1996)
• The orphan receptor Rev-ErbA alpha activates transcription via a novel response element.
  per: Harding, H P, et al.
  Publicat: (1993)
• Identification of heme as the ligand for the orphan nuclear receptors REV-ERBα and REV-ERBβ
  per: Raghuram, Srilatha, et al.
  Publicat: (2007)