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Two receptor interaction domains in the corepressor, N-CoR/RIP13, are required for an efficient interaction with Rev-erbA alpha and RVR: physical association is dependent on the E region of the orphan receptors.

Rev-erbA alpha and RVR/Rev-erb beta/BD73 are orphan steroid receptors that have no known ligands in the 'classical sense'. These 'orphans' do not activate transcription, but function as dominant transcriptional silencers. The thyroid hormone receptor (TR) and the retinoic acid receptor (RAR) act as...

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Uloženo v:
Vydáno v:Nucleic Acids Res
Hlavní autoři: Downes, M, Burke, L J, Bailey, P J, Muscat, G E
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 1996
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146280/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8948627/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.22.4379
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