Two receptor interaction domains in the corepressor, N-CoR/RIP13, are required for an efficient interaction with Rev-erbA alpha and RVR: physical association is dependent on the E region of the orphan receptors.

Lignende værker

• Transcriptional repression by the orphan steroid receptor RVR/Rev-erb beta is dependent on the signature motif and helix 5 in the E region: functional evidence for a biological role of RVR in myogenesis.
  af: Burke, L, et al.
  Udgivet: (1996)
• Transcriptional repression by Rev-erbA alpha is dependent on the signature motif and helix 5 in the ligand binding domain: silencing does not involve an interaction with N-CoR.
  af: Downes, M, et al.
  Udgivet: (1996)
• The orphan receptor Rev-ErbA alpha activates transcription via a novel response element.
  af: Harding, H P, et al.
  Udgivet: (1993)
• The corepressor N-CoR and its variants RIP13a and RIP13Delta1 directly interact with the basal transcription factors TFIIB, TAFII32 and TAFII70.
  af: Muscat, G E, et al.
  Udgivet: (1998)
• Identification of heme as the ligand for the orphan nuclear receptors REV-ERBα and REV-ERBβ
  af: Raghuram, Srilatha, et al.
  Udgivet: (2007)