Methylation inhibitors can increase the rate of cytosine deamination by (cytosine-5)-DNA methyltransferase.

The target cytosines of (cytosine-5)-DNA methyltransferases in prokaryotic and eukaryotic DNA show increased rates of C-->T transition mutations compared to non-target cytosines. These mutations are induced either by the spontaneous deamination of 5-mC-->T generating inefficiently repaired G:T rathe...

Descrizione completa

Dettagli Bibliografici

Pubblicato in:	Nucleic Acids Res
Autori principali:	Zingg, J M, Shen, J C, Yang, A S, Rapoport, H, Jones, P A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146075/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8774911/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.16.3267
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!