Methylation inhibitors can increase the rate of cytosine deamination by (cytosine-5)-DNA methyltransferase.
The target cytosines of (cytosine-5)-DNA methyltransferases in prokaryotic and eukaryotic DNA show increased rates of C-->T transition mutations compared to non-target cytosines. These mutations are induced either by the spontaneous deamination of 5-mC-->T generating inefficiently repaired G:T rathe...
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| Vydáno v: | Nucleic Acids Res |
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| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Oxford University Press
1996
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146075/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8774911/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.16.3267 |
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