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Increased episomal replication accounts for the high rate of adaptive mutation in recD mutants of Escherichia coli.

Adaptive mutation has been studied extensively in FC40, a strain of Escherichia coli that cannot metabolize lactose (Lac-) because of a frameshift mutation affecting the lacZ gene on its episome. recD mutants of FC40, in which the exonuclease activity of RecBCD (ExoV) is abolished but its helicase a...

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Bibliografiske detaljer
Main Authors: Foster, P L, Rosche, W A
Format: Artigo
Sprog:Inglês
Udgivet: 1999
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1460594/
https://ncbi.nlm.nih.gov/pubmed/10224241
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