In vivo degradation of RNA polymerase II largest subunit triggered by alpha-amanitin.

Alpha-Amanitin is a well-known specific inhibitor of RNA polymerase II (RNAPII) in vitro and in vivo. It is a cyclic octapeptide which binds with high affinity to the largest subunit of RNAPII, RPB1. We have found that in murine fibroblasts exposure to alpha-amanitin triggered degradation of the RPB...

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Bibliografske podrobnosti

izdano v:	Nucleic Acids Res
Principais autores:	Nguyen, V T, Giannoni, F, Dubois, M F, Seo, S J, Vigneron, M, Kédinger, C, Bensaude, O
Format:	Artigo
Jezik:	Inglês
Izdano:	Oxford University Press 1996
Teme:	Research Article
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146057/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8760875/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.15.2924
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