In vivo degradation of RNA polymerase II largest subunit triggered by alpha-amanitin.

Alpha-Amanitin is a well-known specific inhibitor of RNA polymerase II (RNAPII) in vitro and in vivo. It is a cyclic octapeptide which binds with high affinity to the largest subunit of RNAPII, RPB1. We have found that in murine fibroblasts exposure to alpha-amanitin triggered degradation of the RPB...

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Detalles Bibliográficos
Main Authors: Nguyen, V T, Giannoni, F, Dubois, M F, Seo, S J, Vigneron, M, Kédinger, C, Bensaude, O
Formato: Artigo
Idioma:Inglês
Publicado: 1996
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC146057/
https://ncbi.nlm.nih.gov/pubmed/8760875
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