Acid binding and detritylation during oligonucleotide synthesis.

Under the conditions normally used for detritylation in oligonucleotide synthesis, the haloacetic acid binds strongly to the oligonucleotide. Acetonitrile also forms a complex with the deblocking acid, in competition with the oligonucleotide, and drastically slows detritylation. Incomplete removal o...

Täydet tiedot

Bibliografiset tiedot

Julkaisussa:	Nucleic Acids Res
Päätekijät:	Paul, C H, Royappa, A T
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Oxford University Press 1996
Aiheet:	Research Article
Linkit:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146054/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8760892/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.15.3048
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