A C-Terminal Domain Targets the Pseudomonas aeruginosa Cytotoxin ExoU to the Plasma Membrane of Host Cells

ExoU, a phospholipase injected into host cells by the type III secretion system of Pseudomonas aeruginosa, leads to rapid cytolytic cell death. Although the importance of ExoU in infection is well established, the mechanism by which this toxin kills host cells is less clear. To gain insight into how...

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Bibliografiske detaljer
Main Authors: Rabin, Shira D. P., Veesenmeyer, Jeffrey L., Bieging, Kathryn T., Hauser, Alan R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2006
Fag:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1459758/
https://ncbi.nlm.nih.gov/pubmed/16622190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.74.5.2552-2561.2006
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