Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells

Suppressor of cytokine signaling (Socs) 3 is a cytokine-inducible inhibitor with critical but selective cell-specific effects. We show that deficiency of Socs3 in T cells had minimal effects on differentiation of T cells to the T helper (Th) 1 or Th2 subsets; accordingly, Socs3 had no effect on IL-1...

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Bibliografiske detaljer
Main Authors: Chen, Zhi, Laurence, Arian, Kanno, Yuka, Pacher-Zavisin, Margit, Zhu, Bing-Mei, Tato, Cristina, Yoshimura, Akihiko, Hennighausen, Lothar, O'Shea, John J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2006
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1459629/
https://ncbi.nlm.nih.gov/pubmed/16698929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600666103
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