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Synthesis and Preliminary Chemotherapeutic Evaluation of the Fully C-Linked Glucuronide of N-(4-Hydroxyphenyl) retinamide (4-HPR)

All-trans retinoic acid (atRA) analogues such as N-(4-hydroxyphenyl) retinamide (4-HPR) are effective chemopreventive and chemotherapeutic agents but their utility has been hampered by dose-limiting side effects. The glucuronide derivatives of 4-HPR, the oxygen-linked 4-HPROG and the carbon-linked 4...

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Autors principals: Walker, Joel R., Alshafie, Galal, Nieves, Nirca, Ahrens, Jamie, Clagett-Dame, Margaret, Abou-Issa, Hussein, Curley, Robert W.
Format: Artigo
Idioma:Inglês
Publicat: 2006
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1459539/
https://ncbi.nlm.nih.gov/pubmed/16412653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2005.12.044
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