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Histidines, heart of the hydrogen ion channel from influenza A virus: Toward an understanding of conductance and proton selectivity
The heart of the H(+) conductance mechanism in the homotetrameric M2 H(+) channel from influenza A is a set of four histidine side chains. Here, we show that protonation of the third of these imidazoles coincides with acid activation of this transmembrane channel and that, at physiological pH, the c...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1458985/ https://ncbi.nlm.nih.gov/pubmed/16632600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0601944103 |
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