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Hydrogen-Bonding Partner of the Proton-Conducting Histidine in the Influenza M2 Proton Channel Revealed From (1)H Chemical Shifts

The influenza M2 protein conducts protons through a critical histidine (His) residue, His37. Whether His37 only interacts with water to relay protons into the virion, or whether a low-barrier hydrogen bond (LBHB) also exists between the histidines to stabilize charges before proton conduction, is ac...

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Detalhes bibliográficos
Main Authors: Hong, Mei, Fritzsching, Keith J., Williams, Jonathan K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631546/
https://ncbi.nlm.nih.gov/pubmed/22931093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja307453v
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