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Desensitization of mechano-gated K(2P) channels

The neuronal mechano-gated K(2P) channels TREK-1 and TRAAK show pronounced desensitization within 100 ms of membrane stretch. Desensitization persists in the presence of cytoskeleton disrupting agents, upon patch excision, and when channels are expressed in membrane blebs. Mechanosensitive currents...

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Detalhes bibliográficos
Main Authors: Honoré, Eric, Patel, Amanda Jane, Chemin, Jean, Suchyna, Thomas, Sachs, Frederick
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1458984/
https://ncbi.nlm.nih.gov/pubmed/16636285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600463103
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