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Determinants of specific RNA interference-mediated silencing of human β-globin alleles differing by a single nucleotide polymorphism
A single nucleotide polymorphism (SNP) in the sickle β-globin gene (β(S)) leads to sickle cell anemia. Sickling increases sharply with deoxy sickle Hb concentration and decreases with increasing fetal γ-globin concentration. Measures that decrease sickle Hb concentration should have an antisickling...
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| Główni autorzy: | , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
National Academy of Sciences
2006
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1458679/ https://ncbi.nlm.nih.gov/pubmed/16585504 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0601309103 |
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