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The adaptor protein Nck interacts with Fas ligand: Guiding the death factor to the cytotoxic immunological synapse
The Fas ligand (FasL) is a key death factor of cytotoxic T lymphocytes and natural killer cells. It is stored intracellularly as a transmembrane protein of secretory lysosomes. Upon activation, these vesicles are transported to the cytotoxic immunological synapse (IS), and FasL becomes exposed to th...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2006
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1458672/ https://ncbi.nlm.nih.gov/pubmed/16595635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508562103 |
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