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Progression of prostate cancer by synergy of AKT with genotropic and nongenotropic actions of the androgen receptor

Classic work by Huggins and Hodges demonstrated that human prostate cancer regresses dramatically during antihormonal therapy but recurs frequently with androgen independence. Perturbations in the androgen receptor (AR) and PTEN–AKT signaling axes are significantly correlated with the progression of...

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Main Authors: Xin, Li, Teitell, Michael A., Lawson, Devon A., Kwon, Andrew, Mellinghoff, Ingo K., Witte, Owen N.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2006
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1458510/
https://ncbi.nlm.nih.gov/pubmed/16682621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602567103
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