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Diastereomeric specificity of 2',3'-cyclic nucleotide 3'-phosphodiesterase.

The diastereomers of adenosine and uridine 2',3'-cyclic phosphorothioates were tested as substrates for 2',3'-cyclic nucleotide 3'-phosphodiesterase from bovine brain. The enzyme cleaves the Sp (or exo) diastereomers efficiently, whereas the Rp (or endo) diastereomers are resistant to hydrolysis, ev...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Heaton, P A, Eckstein, F
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 1996
Sujets:
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC145708/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8600451/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.5.850
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