Antisense oligonucleotide containing an internal, non-nucleotide-based linker promote site-specific cleavage of RNA.
We have designed and synthesized a series of novel antisense methylphosphonate oligonucleotide (MPO) cleaving agents that promote site-specific cleavage on a complementary RNA target. These MPOs contain a non- nucleotide-based linking moiety near the middle of the sequence in place of one of the nuc...
Збережено в:
| Опубліковано в:: | Nucleic Acids Res |
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| Автори: | , , , , , , , , , |
| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
Oxford University Press
1996
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| Предмети: | |
| Онлайн доступ: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC145679/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8604321/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.4.760 |
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