Antisense oligonucleotide containing an internal, non-nucleotide-based linker promote site-specific cleavage of RNA.

We have designed and synthesized a series of novel antisense methylphosphonate oligonucleotide (MPO) cleaving agents that promote site-specific cleavage on a complementary RNA target. These MPOs contain a non- nucleotide-based linking moiety near the middle of the sequence in place of one of the nuc...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Reynolds, M A, Beck, T A, Say, P B, Schwartz, D A, Dwyer, B P, Daily, W J, Vaghefi, M M, Metzler, M D, Klem, R E, Arnold, L J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC145679/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8604321/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.4.760
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