A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt

The oncoproteins P3k (homolog of the catalytic subunit of class IA phosphoinositide 3-kinase) and Akt (protein kinase B) induce oncogenic transformation of chicken embryo fibroblasts. The transformed cells show constitutive phosphorylation of the positive regulator of translation p70S6 kinase (S6K)...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Aoki, Masahiro, Blazek, Erik, Vogt, Peter K.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC14557/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11134523/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.011528498
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